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The hope was that one vector would allow for the expression of multiple miRNA species and isomirs (one miRNA precursor can give rise to two miRNA "species" (from the 5p and 3p arms, respectively), that can each come in multiple forms or "isomirs"), and that this would optimally mimic the condition prevailing in vivo at minimum cost.
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Expertise on this oversight committee would optimally include patients, including previous participants in QI/QIR, and experts in conducting QI and QIR, in addition to experts in ethical oversight.
This hybrid system for biomanufacturing would optimally be used where N. glauca is not present and in physical isolation of N. tabacum production to provide total bioconfinement.
Adoption of this treatment approach in the ICU would optimally need to be based upon a demonstration of reduced need for other healthcare resources such as mechanical ventilation.
This step during the processing work-flow would optimally be replaced with the automatic evaluation of frame-to-frame motion based on similarity metrics [39], but such metrics are challenging to implement in practice due to the gradually changing image contrast with increasing b-values during the acquisition scheme.
Staining was carried out at pH 9.2 and as there is a possibility that different AP isoform would optimally stain at different pHs and this may also contribute to the variation seen in AP activity on the IEF gel.
If the brain works in the Bayesian way, it would optimally use the prior knowledge".
A set of design values which would optimally balance the levels of luxuriousness, attractiveness, and overall satisfaction are obtained.
Such studies would optimally employ RNA sequencing technologies, and would be expected to identify a larger number of exosome-expressed miRNA.
Aim of this study was to investigate the effect of the preparation parameters on the characteristics of lipospheres that would optimally fit to a lab-on-a-chip platform.
For non-smooth objects, we would optimally also compute some kind of a local curvature measure (e.g. by using dn/dp), rather than merely using first derivatives (see figure 3), but in the interest of saving time we assumed our final image would exclusively contain smooth foam objects and thus not be noticeably affected by this type of artifact.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com