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The CORUM dataset used in this work was generated by overlaying multi-protein complexes described in the CORUM database with the binary interactions from the iRefIndex resource, while the HeLa dataset was derived by its authors by applying the CLusterOne method to a high confidence PPI network.

Although parameter variability to account for interindividual variability in plasma and tissue concentration profiles was incorporated in the PBPK model, this was not possible for the PD model because the published PD model adapted for this work was generated from fitting of average profiles.

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All the structures presented in this work were generated using PyMOL.

The results presented in this work were generated using mostly collocation points and.

All mAbs used in this work were generated in mice, including W6/32 (IgG2a), directed against class I MHC molecules, anti-HLA-G mAb MEM-G/09 (IgG1), anti-CD85J/LIR-1 mAb- HPF1 (IgG1), anti KIR2DL1 mAb HP3E4 (IgM) (a kind gift from M. Lopez-Botet, DCEXS Universitat Pompeu Fabra, Spain), and anti- KIR2DL2 mAb GL183 IgG1).

Additional strains used in this work were generated in this study.

Additional strains used in this work were generated in this study using the standard genetic procedures.

All three-dimensional models of the functional nanoparticles presented in this work were generated as detailed in Methods.

All three-dimensional models of the functional nanoparticles presented in this work were generated using custom-written PyMOL scripts (http://www.pymol.org/).org/

To narrow the region further, candidate SSR marker primer pairs for this work were generated using the Zebrafish Genome SSR search website (Massachusetts General Hospital, Charlestown, MA 02129; http://danio.mgh.harvard.edu/chrMarkers/zfssr.html).html

It is worth noting that the Hi-C data sets used in this work were generated from a population of cells rather than a single cell such that the gene-gene interaction data is an average of the spatial interactions of a population of cells whose genome conformation may vary.

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