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As the attention for drugs' HLA liability is on the rise, we believe this work participates in encouraging the use of molecular modeling for reliably studying and predicting HLA drug interactions.
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All of the authors of this work participated in the concept and design of the study, as well as data analysis, interpretation, and manuscript generation.
It is likely that additional mechanisms not investigated in this work, participate during this long-term selection in macrophages.
KG and WKY contributed equally to this work, participating in study design, data acquisition and analysis, and preparation of the manuscript.
DAW developed the concept for this work, participated in study design, secured funding, assisted with kinase assays and edited the manuscript.
FALC and MGP contributed equally to this work, participated in the initial conception of the study, sample harvest, performance of the assays, data analysis and manuscript preparation.
AHP developed the initial idea for the work, participated with simulations and drafted the manuscript.
BL designed the work, participated in analyzing the data and finalized the manuscript.
BL initiated the work, participated in the data analysis and wrote the draft manuscript.
JAG coordinated the work, participated in the discussion of all experiments and wrote the manuscript.
IS carried out all the experimental part of the work, participated in bioinformatics analyses and prepared the manuscript.
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