Despite comparative studies of fetal wound healing in which no scar is produced, the fact remains that insights from this work have failed to produce therapies that can regenerate adult human skin.
In most cases when a listener complains that he does not understand a work of music, he means, not that he has failed to grasp its expressive content, but that the work has failed to cohere for him as a single and satisfying object of experience.
Earlier attempts to place the work had failed.
But their work has failed to ignite the passions of the law-enforcement community.
As I pointed out some 20 years ago, the problem is not that condom-based prevention work has failed but that prevention work itself has so often been actively prevented, not least in the United States.
As previous work has failed to detect ADAMTS-12 in normal human tissues and cells [21], we performed Western blot analysis to confirm that this ADAMTS subtype was expressed in first trimester human placenta in vivo and in trophoblastic cells in vitro.
Despite the preparation of numerous cADPR analogues, previous work has failed to address the critical issue of the pyrophosphate.
However, previous work has failed to find such a relationship based on conventional volumetry of T1-weighted MRI [Dreifuss et al., 2001].
Indeed, more recent work has failed to find any antagonistic action of kynurenic acid at α7 receptors (Mok et al., 2009; Dobelis et al., 2012), suggesting that the original observations may have been made under highly selective conditions that are not generally applicable.
Studies in which endothelial cell lines were infected with bacteria such as Escherichia coli and S taphylococcus aureus have shown consistent evidence of endothelial cell apoptosis [ 27- 31], but in vivo work has failed to show consistent results [ 32, 33] with the easy detachment of cells into the media, making detection difficult.
