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However, When DHEAS or PREGS were co-injected with a sub-effective dose of αβmeATP, mechanical allodynia was developed and this was dose dependently blocked by pre-injection of the P2X antagonist, TNP-ATP.
Sera obtained from mice 24 h after Ge-132 administration displayed the greatest antitumour effect and this was dose dependent.
This was dose dependent, observed both in concurrent and sequential combinations, and also seen with other alkylating agents.
This was dose dependently inhibited by treatment with Exon8apab (IC50 = 0.115nM 95 % CI 0.07 0.19, Fig. 2b).
Neutropenia was the major toxicity reported with docetaxel in Phase I trials; this was dose- but not schedule-dependent (Cortes and Pazdur, 1995).
As shown in Figure 8A: a-d, the expression of TLR4 is clearly increased by LPS and this was dose dependent.
Similar(53)
This was dose-dependent, induced nearly complete inhibition of twitch force at high-doses and was partially reversible.
Grade 4 thrombocytopenia occurred in two patients (one at the 50 mg m−2 and one at 60 mg m−2 doses of irinotecan) and this was dose-limiting toxicity.
If irinotecan was omitted two times or more due to any toxicity or radiotherapy and daily carboplatin was postponed for more than one week because of grade 3 haematological toxicity or grade 4 oesophagitis, we decided this was dose-limiting toxicity.
The mutagenic activity of this agent and others in this series was dose dependent but weak.
This toxicity was dose limiting for carboplatin in this schedule.
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