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In Marin specifically we went through this very stringent recruitment process to get, well, the best and brightest frankly from the Bay area.
This very stringent criterion ensures that when we say that one method is more accurate than another, we have the ultimate confidence that this is almost certainly true.
Using this very stringent approach, four different clusters (A to D) were identified by Pearson correlation analysis, corresponding to the different types of gene expression behavior in response to aging and/or treatment (Fig. 3).
Thus we applied this very stringent threshold to select 176 bona fide modulated miRNAs across the 66 experiments.
In total 7,779 (32.6%) of expressed annotated mouse transcripts used in this analysis satisfied this very stringent criterion.
This very stringent filtering regime was designed to reduce the false positive rate with already 39 identified variants confirmed as ENU mutations (data not shown).
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This consideration reveals that the very stringent classification of ownership is not very appropriate to investigate the boundaries of meta-organizations.
This low level of background probably reflects the very stringent purification conditions used during CLASH.
This is both very stringent and very conservative.
Yet, this correction is very stringent and over-conservative – in particular when correcting for testing all phenotypes and all strains.
This is a very stringent assumption since for instance suboptimal peptides sharing the ligand binding-core are counted as negatives even though they could be presented on the HLA molecule.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com