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This variant includes the transfer of 3-phosphoglycerate from the mesophyll to the bundle sheath, where it is converted to phosphohydroxy pyruvate by 3-phosphoglycerate dehydrogenase.

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A region of high regulatory activity is located around 5 kb downstream of this variant, including binding sites for transcription factors, including GATA1, GATA2, GATA3, and NR2F2.

Analysis of genes altered in just those strains expressing this variant, including three genes involved in cell cycle control: raf oncogene (X03484), cyclin D1 (Z29087), and BTF2 (U72649) may further support an association between OTQ exposure, p53 variant status and carcinogenesis [ 36- 38].

The second variant includes GPU Parallel Protecting (GPP) and GPU Parallel Unprotecting (GPUP).

Therefore, another variant includes the packet gateway in the signaling path.

Investigating a potential functional role of the variants included in this study, revealed that rs2286936 of ACADL is a non-synonymous coding variant and thereby could impact on the measured phenotypes.

PE susceptibility related to VEGF haplotypes has been considered in a very few studies; however, none of them has genotyped all the variants included in this work.

It is likely that this set of variants includes real risk factors.

This set of novel variants includes 1,547 SNPs and 4,577 indels having alleles not reported in dbSNP 138 [ 19].

One of the nine studied variants was the already known risk factor HLA-DRB1 SE [ 1]; this variant was included in the present study for a complete overview.

Failure to identify a known 36 bp complex indel in CDKN2A was complicated by low read depth owing to high GC content for this gene; this variant was included in subsequent analyses.

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