The finding that illness severity decreased over time in control patients, but remained constant in the cases, supports the notion that severe thrombocytopenia probably largely reflects the unfavourable course of the underlying disease and possibly the aggravating role of thrombocytopenia itself.
Indeed, this unfavourable trend continued to the end of the communist era.
This is contrary the idea of some family doctors who are reluctant to diagnose their patients as having CFS, as they are afraid that this will facilitate an unfavourable course of the condition.
Main reasons to perform a caesarean section were: (a) autonomy; (b) an unfavourable course of delivery in the absence of motivation for a natural childbirth; (c) litigation.
In our series, only 1/5 patients with an unfavourable course had affected nodes.
Undeniably, the risk of an unfavourable course of the disease increases in proportion to age.
There was a significant correlation between 5T4 expression in the malignant cells and unfavourable course of disease (P < 0.001).
In this study we also detected a previously unreported association between the bFGF gene polymorphism and a more unfavourable course of the disease.
PHM with a favourable course (treatment response) in the first 48 hours on the ICU had a better survival rate (95.7%) than an unfavourable course (33.3%) (P < 0.001).
Apart from a long, potentially unfavourable course, we found no sign or symptom that was particularly associated with D. pigrum keratitis.
