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Fourth, this trial utilized preliminary versions of the RAD.

This trial utilized aggressive PN glucose loading in the early PN group via a low-protein PN product, leading to a significant nonprotein calorie load (with low protein delivery) versus the late-PN group.

49 This trial utilized a randomized, crossover design and each patient received denosumab 60 mg subcutaneously every 6 months for 12 months and alendronate 70 mg orally every week for 12 months, one after the other.

Another potential weakness is that this trial utilized bolus dosing opposed to continuous supplementation that was utilized in prior studies on the affects of omega-3 fatty acids, GLA and antioxidants on ALI.

Although this trial utilized a more conservative and better-tolerated dose titration protocol than FREEDOM-C or FREEDOM-M, it failed to meet the primary end point, with a +10 m placebo-corrected Hodges Lehmann between-treatment median difference in 6MWD at 16 weeks (P=0.089).

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This trial utilizes carefully defined eligibility criteria that allows for sufficient numbers of events while excluding slow-progressing patients.

This trial utilizes an intervention that has been proven to be effective in community-dwelling older people, and tests whether these results can be extrapolated to the residential care setting within a more supervised and supported environment.

Given the challenges of random assignment in large complex public health interventions [ 54], the trial utilized a quasi-experimental design.

To enable a comparison of an IV regimen of decitabine with the standard subcutaneous cytarabine regimen, the trial utilized an open-label study design.

Each trial utilized a flea-naïve cat host, minimizing the possibility of cat-derived, immune-mediated rickettsial clearance in feeding fleas.

One trial utilized only time domain analysis [ 26] and one frequency domain [ 27].

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