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The pragmatic nature of this trial means that we will not seek to influence this arrangement.
The nature of the treatments involved in this trial means that blinding of the physiotherapists and participants is not possible.
He considers that this trial means that it is now unethical to ask patients to posture particularly because several patients who did posture fed back to him how uncomfortable they found posturing.
From a clinician's perspective, the differences seen in the rate of nocturnal hypoglycaemia in this trial means that to avoid one nocturnal confirmed hypoglycaemic episode one would need to treat 1 patient for 7 months with IDeg or if 100 patients are treated for 1 year with IDeg there would be 179 fewer confirmed nocturnal hypoglycaemic episodes than with IDet as the comparator.
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What's more, the rules of this trial mean I can have another round of chemo in the meantime.
According to the Washington Post, the legal standard to which the cases were subjected in this trial meant that "the outcome will hinge not on scientific standards of evidence but on a legal standard of plausibility what one lawyer for the families called '50 percent and a feather'".
Unfortunately, missing data from individual patients in this trial meant we could not investigate further.
Moreover, in this trial, mean PG was similar with IDeg and IGlar throughout the hypoglycaemic clamp procedure.
In this trial, mean trough 'total' AZD3409 concentrations in the twice daily dosing levels ranged between 31.3 and 434 ng ml−1 (assuming that AZD3409 ester and AZD3409 acid are the main metabolites in plasma).
Televising the trial means no one can convincingly complain about inaccessibility.
The central importance of having a participant-reported outcome measure for this pragmatic trial means that perceptions of outcome may be open to bias.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com