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As mentioned earlier the level of functional annotation of isoforms in existing databases is too low to be useful, making this task particularly challenging.

While these questions have also been addressed both biologically and computationally, the sheer magnitude of this task particularly from an empirical perspective has driven significant development in the bioinformatics of miRNA-target prediction and systems-based analysis of miRNA function.

The rarity and diversity of somatic events that occur on a background of tumor heterogeneity, normal contamination, technical artifacts, and genomic complexity makes this task particularly challenging [ 1, 12].

In terms of the automated acquisition of phenotypes from text, what makes this task particularly challenging is that it encompasses a range of basic semantic types (e.g. cells, tissues, biological functions) and text types, e.g. scientific texts, clinical trial reports, electronic patient records (EPRs).

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The analysis of the data shows the navigational paths that students went through at the very starting point of the task (particularly irrelevant given no comparative research).

"We recognise that the government is engaging with industry stakeholders but are not convinced that the level of engagement and expertise within government are commensurate with the scale of this unprecedented task, particularly given the government's commitment to trigger article 50 by the end of March 2017," wrote the Lords' EU internal market and EU external affairs sub-committees.

Avoiding confrontations with relievers is a harder task, particularly in this era of specialization.

This is again a difficult task, particularly given that evaluation timelines can last 5 or more years.

But this is not a simple task, particularly when it involves assets with risk exposures far into the future and which are traded so rarely that there is no good market benchmark for setting the price.

This can be a hard task, particularly if the design system contains dependency between variables.

This is not an easy task, particularly in the case of subclinical varicocele.

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