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This systemic immunity could be disrupted either by macrophage depletion during immunization or by lymphadenectomy after challenge.
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In addition, mice inoculated IP with LVSΔ1423/1422 were also protected against low dose IN challenge with LVS, demonstrating that systemic immunity to this mutant was adequate for protection in the respiratory tract.
The gut-associated lymphoid tissue response following bacterial challenge and its crosstalk with the systemic immunity via the lymphatic system is the key factor related to the aggravation of systemic inflammation and death in sepsis.
This peripheral immunization resulted in systemic immunity that induced tumor rejection in either subcutaneous or established intracranial tumors [18], [19].
Although C. elegans has no adaptive immune system, it has comprehensive systemic immunity.
Lethally irradiated wild-type cells were also successful in treating some established tumours, although this did not induce any systemic immunity.
The objective of this study was to define immune changes in lower genital and systemic immunity associated with normal pregnancy.
Dronca et al. (2011) showed that immunosuppressive factors in the tumor microenvironment may impair not only local immune responses but also disturb systemic immunity.
Much research has been devoted toward generating efficient systemic immunity against tumors, which commonly evades immune detection in patients.
Nevertheless, the immune system must be involved as local IL-2 treatment causes systemic immunity, that resides in CD3+ lymphocytes or CD4+ and CD8+ lymphocytes [ 69, 70].
Furthermore, treatment stimulated an initial non-specific immune reaction that lead to a systemic immunity.
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