Substantial duration of contact is thought to be required for the cell-cell interaction to be effective, e.g. for the TC to deliver the cytotoxins that kill the APC that is infected by viruses.
We also found that the total ventilated lung area remained unaffected during mechanical ventilation of substantial duration.
Adaptation with a slow time constant could explain the fairly substantial duration of the local search but not its sharp transition to a global search.
Thus, the populations had substantial duration of exposure to various factors in their home regions and little exposure outside of these regions.
Moreover, the interventions (particularly those belonging to Avahan) were in place for substantial duration in 2009-10 when second round of the survey was undertaken.
While this might be a significant factor in brain examinations that include dynamic PET measurements of substantial duration, the increase in scan time for the head and neck region is much less pronounced.
Although SCEAM was developed only a decade ago, ten years is a substantial duration in which developments and changes in care practices and legislation can occur, as well as in technology relevant to both care practice and care environments.
Moreover, treatment must likely occur over a substantial duration of time, since macrovascular outcome events are known to be late complications of a progressive multifaceted pathogenic process that spans decades [ 7, 8].
Only longitudinal studies of substantial duration that incur natural progression of disease (or biomarkers thereof) would be of value to highlight a retarded progression of age-related diseases induced by therapeutics (e.g., similar to those using statin drugs [ 20, 21], fish oil [ 22], or vitamin supplements [ 23] for prevention of cardiovascular disease).
However, most of these patients continued on antipsychotic polypharmacy for a substantial duration and only a small proportion of those patients (30%) were deemed to have gone through medication changes as polypharmacy ceased within the first 60 days after medication initiation.
With a few exceptions, recovery studies did not monitor vegetation for substantial durations, thus limiting adequate evaluation of the recovery trajectory.
