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Associations were generally stronger among this subset, supporting such an accumulation model for this particular disorder.
Instead, CREB family motifs (CREB1 and ATF3) were enriched in this subset (Supporting Information Table S7).
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IFN-γ expression, induced by both TLR4 and TLR8 agonists, was restricted to the CD161++CD8+ T cell subset (Supporting Information Fig. 3A and B).
However, when comparing a_cell types with one another, the "core UP" gene set was significantly induced to higher levels in each activated DC subset as compared with each activated lymphocyte subset (Supporting Information Fig. 4).
As expected, ETS exposure during pregnancy was significantly correlated with maternal and cord cotinine levels both in the entire cohort and in the present subset, supporting self-reported ETS as a reliable measure of ETS exposure.
The only cell population that contained statistically significantly more cells in the C2ABM spleen was the CD4+ T-cell subset (Supporting Information Table 3, p<0.05), but when we gated on Vα2+ cells, the number of cells in each population was equivalent between the two genotypes.
This minimal subset supports all the policies of the case study, but remains generic in order to guarantee its wide applicability.
Thus, our findings of different impact of PMH use, where the reduced risk seems to be restricted to the ACPA positive subset, support the notion of RA as two different disease entities with different/distinct etiology.
These increases compare favorably to those in the subsets supported by presence of interologs (above) except for human, where the increase is only 60% as great.
Whether this reflects a beneficial qualitative shift in Treg subsets supporting TB immunity remains to be established.
The results demonstrate that this protocol allowed for virtual reconstitution of white blood cell subsets (Supporting Information Fig 2) and enabled prominent lesional accumulation of donor leucocytes (Supporting Information Fig 3).
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