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The single isolate in this subset of samples in which histidine-rich protein could be detected was positive for both pfhrp2 and pfhrp3.
This subset of samples also harbored frequent homozygous deletion of 9p21 spanning the Ink4a/ARF locus (75% vs 35%, p = 2.0e−7).
This subset of samples contained a 625-bp deletion between bases 189820 and 190444 (genome positions based on MPXV-COG_2003_358).
Another explanation might be that this subset of samples involves an alternative tumorigenic pthway which does not involve chromosome 22-located genes.
This subset of samples was used to verify the independence of the proposed rec-gE indirect ELISA relative to the diagnostic blocking ELISA.
55 No additional mutations were identified in this subset of samples (n=16), suggesting that alternate mutational mechanisms also exist within the PMS2 locus.
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The adjusted OR associated with the E4 genotype group to develop ≥70% stenosis was 1.61 (95% CI: 0.59 5.23; P = 0.38) in this subset of sample.
To verify that chip effect differences between the HGU133plus2 and HGU133A did not influence the identification of bimodal genes, this procedure was applied to the subset of samples both including and excluding HGU133A arrays.
All mutations identified by Pyrosequencing were then confirmed and, in addition, one more mutated sample was identified in this subset of 56 samples.
The results of the subset of samples from sequential months are reported.
In contrast, ER and PgR status, patient age and histological grade were of no prognostic significance in this subset of tumour samples.
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