For the purpose of the study, wound dehiscence is defined as separation of both the skin and muscle layers.
For the purpose of this study, a wound complication was defined as any wound breakdown that occurred before the completion of adjuvant chemotherapy and radiotherapy and that needed surgical debridement, dressing, or packing or any persistent discharge from the wound.
As demonstrated in this study, surgical wound palpation might elicit different reactions depending on individual features, intensity of pain, discomfort or stress [ 13, 24, 32, 35, 36].
For this reason and due to the relative ease of monitoring donor sites, this type of wound has become the ideal model to study wound healing in vivo[ 26].
In a previous study, wound healing was slowed after mate separation (2 days) in monogamous California mice, Peromyscus californicus, but not polygynous white-footed mice, P. leucopus.
Moreover, we adapted HSEs to study wound repair in a manner that simulates the chronology of events that occur during re-epithelialization in human skin [13], [14].
In this study, mechanical wounds, fungal elicitors and salt solution were applied to induce the formation of 2- 2-phenylethyl) chromones, which are the principal compounds in agarwood.
Considering the scope of this study, the dermal wound created by punch biopsy was adopted as the wound model to avoid excess bleeding, severe infection, and possible complications due to the wound creation in deep tissues.
Furthermore, in vivo experiments are conducted on a mouse model to study wounds treated with the chitosan/γ-PGA PECs.
