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This study will enroll 150 children between birth and 17 years of age with chronic symptomatic heart failure caused by systemic ventricular systolic dysfunction.

This study will enroll 200 older adults who report functional disability in the back and neck regions.

This study will enroll more than 8,000 subjects with type 2 diabetes and renal dysfunction and aims to investigate the efficacy and safety of linagliptin versus placebo on both CV and renal microvascular outcomes.

This study will enroll 675 patients with primary ICH within 3 hours of symptom onset, with the primary goal of reducing disability and improving clinical outcome after 3 months.

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Subjects will be randomized in a 2 1 randomization scheme to receive human MSCs or Plasma-lyte A placebo; the study will enroll 60 patients who achieve a stable clinical baseline and receive the investigational product.

Part A of the study will enroll patients with any level of HRG mRNA expression, and the statistical analysis will assess HRG-high and HRG-low biomarker groups for clinical benefit as measured by PFS to confirm the results of the HERALD study.

It is planned that this first study will enroll 60 subjects who will receive up to a maximum of 52 weeks of treatment.

This prospective study will enroll a cohort of 1100 adult participants with a broad range of AKI and matched hospitalized participants without AKI at three Clinical Research Centers, as well as 100 children undergoing cardiac surgery at three Clinical Research Centers.

This prospective epidemiologic study will enroll new inmates at Federal Medical Center (FMC) Devens (Devens, MA) and FMC Carswell (Fort Worth, TX) and follow all consenting participants over a five-year period.

To achieve these objectives, the studies will enroll pregnant women and their children born within approximately 6 months of the baseline survey.

The study will enroll approximately 360 patients (180 per arm), allowing for a 10% drop-out.

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