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This study was originally planned as a phase 1/2, multicentre, open-label study (ClinicalTrials.gov; Unique ID: NCT00959946); the phase 1 portion was completed and the results are reported here.
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The study was originally planned to have a power of 90%, but with the estimated overall failure rate of 22% and average sample of size of 835.5, the power of current study is 79.5%.
The study was originally planned as a controlled before-and-after study.
The study was originally planned to have 200 participants per arm providing 86.1% power to detect an increase in CPR from 35 to 50% at α = 0.05 but was stopped early for financial reasons.
The study was originally planned to include data on 1027 FMU participants and 1027 control participants over a period of 3.5 years, starting 1 January 2005; however, in October 2006, the local authorities unexpectedly announced the closure of its two FMUs.
Simulation in this study was originally designed for the prediction of experiments and later explanations.
This study was originally conceived by LW, JR & BH.
This launch was originally planned for the end of 2010.
This variant was originally planned to be designated AV-8D.
This freeway was originally planned as a parkway between the two cities in 1932 that never materialized.
Secondly, the cohort used was originally planned for the study of congenital malformations, not for the outcomes studied here.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com