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Similarly, the recent SPLIT trial also failed to demonstrate a significant difference between saline and a balanced solution (Plasma-Lyte) in critically ill patients [26], although this study has been subject to a lot of criticisms [21].
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Unfortunately the interpretation of the results of this study has been subjected to a methodological pitfall.
Several of the missense substitutions observed in this study have been subjected to functional assays in one or more published works.
The questionnaire on physical activity used in this study has been validated on 1,400 subjects.
This study has been conducted on 269 subjects over 50 with hypertension and/or CRF, unrelated to other known causes of renal disease.
This study has been conducted selecting patients from 22 subjects enrolled in an open-label randomized Institutional Review Board-approved trial of IL-2 immunotherapy in association with cART versus cART alone, published by Marchetti et al [6].
This study has been approved annually by the human subjects review boards of the National Cancer Institute and the University of Minnesota.
This study has been performed on an underdeveloped oil reservoir, subjected to immiscible gas injection method, and situated in the southern part of Iran (Fig. 1).
Further information on the characteristics of the subjects in this study has been provided in that paper [ 11].
All subjects in this study have been reported negative for FRAXA mutations and subjects with mental retardation were reported to have normal G-banded karyotypes at 550-band resolution.
Some of the behaviours observed in this study have been described previously in cattle subjected to orchiectomy.
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