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This stringent approach led to the identification of 106 independent expression correlates for the ten risk factors (Table 6), a much reduced number compared to the 1,662 expression traits previously identified by the one-to-one association analysis presented in Table 5.
Using this stringent approach only two genes met the criteria.
This stringent approach identified 1,543 kiwi genes.
This stringent approach had the disadvantage that no data was recorded for some capillary segments.
This stringent approach (261 SNPs validated >1000 putative sites) was necessary to overcome uncertainties associated with contig assembly.
Using this stringent approach and paired-end information, we were able to uniquely map read pairs to these repeated loci, including through short stretches of non-unique sequence.
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Using this very stringent approach, four different clusters (A to D) were identified by Pearson correlation analysis, corresponding to the different types of gene expression behavior in response to aging and/or treatment (Fig. 3).
Using this highly stringent approach, there were no variants present at >0.2% heteroplasmy in any of the cloned or genomic DNA templates (Fig. 1).
This more stringent approach may result in randomizing subsequent patients to a potentially inferior treatment, an option that seems at odds with safety ethics.
This more stringent approach is advantageous because it allows us to find disease-causing genes that lie in existing disease intervals but that were previously not associated with the disease.
On the other hand, the variable RACING INTENSITY maintained significance also in this multivariable, more stringent, approach (p < 0.001), with the "23 to 32 races per year" level showing significantly smaller IRR than lower intensities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com