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The phrase "this significance" is grammatically correct and can be used in written English.
It is typically used to refer to the importance or meaning of something that has been previously mentioned or is about to be mentioned. Example: "The discovery of a new species of plant in the rainforest holds great significance for the study of biodiversity. This significance cannot be overstated, as it could potentially lead to advancements in medicinal research."
Exact(59)
"I think any governor that puts a plan on the table of this significance deserves a vote," Mr. Rowland told reporters late this afternoon.
Deals of this significance do not come easily.
Most responses we have seen thus far, however, are desperately lacking any sense of this significance.
Maybe it's because there aren't that many places here to see material of this significance in the decorative arts.
"It is unwise for any defendant to proceed without counsel, especially in a case of this significance," she said.
That goal, however, failed to kick-start the Pittodrie side in the manner befitting a game of this significance.
But defeats of this significance make that mitigation look fairly weak – even if the Wigan coach, Shaun Wane, refused to panic.
Are there alternative explanations for this significance?
This significance was confirmed by a bootstrapping approach.
This significance was lost with the HAMD-17 scale.
This significance is examined for the problem of producing least-cost structures.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com