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This shortcoming affects particularly signaling pathways: without solid, consistent and unambiguous representations, hypotheses and analyses based on them are affected by an inability to do any proper computational analysis in the worst case, and a loss of power, in the best case.
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Among the several oh-too-true observations in comedian Jon Stewart's take-down of Steve Jobs was the suggestion that Jobs is obsessed with the technical demerits of Flash when a vastly bigger shortcoming affects the iPhone: an AT&T network that makes it unpleasant to use the phone as, well, a phone.
Among the shortcomings affecting the program in discussion, reference can be made to the late start of PE.
This shortcoming highly affected the implementation of the program.
However, two shortcomings affected the containment strategy.
There were some shortcomings affecting the sample collection, which were associated with the UF-device.
Combined, these technical shortcomings affect the validity of some expression signatures and limit the efficacy of projecting expression signatures between data sets.
While this shortcoming does not affect the clinical performance of large bore prostheses in aortic or iliac position, it contributes significantly to the high failure rate of small- to medium-sized grafts (SMGs).
The former shortcoming clearly affects the peace of mind of users regarding their privacy.
While PAS/SUS data do differ from HES, the differences are minor so we believe this shortcoming is unlikely to affect the accuracy of the predictive model substantially.
Any shortcoming in this stock directly affects our ability to conduct valid and reliable benefit transfers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com