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This research manuscript has no conflict of interest.

Funding for this research and manuscript was provided by Amylin Pharmaceuticals , Inc

This company does not fund this research or manuscript in any way.

The authors have no conflict of interest to disclose in regard to this research or manuscript.

The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-244X/14/98/prepub The individuals who contributed to this research and manuscript all met the criteria for authorship.

All mentioned authors made substantial contribution to this research and manuscript: TJ carried out all components of the research including development of research protocol, data collection and analysis, and drafted the manuscript.

All mentioned authors made substantial contribution to this research and manuscript: TJ was involved in research protocol development, submission of ethics application, and different phases of the data collection and analysis, and writing of manuscript.

Our research manuscript was submitted to Climate Research and was published after undergoing a routine peer-review process.

RS: participated in study design (immunologic research), manuscript revision.

SCH carried out the literature research, manuscript preparation and editing.

This research and this manuscript were commissioned and sponsored by Bayer.