Of course, ensuring that a study population is comprehensive in this way requires substantial effort, but there are gains of equal degree in terms of achieving results with external generalizability.
It certainly requires substantial effort simply to concentrate on, let alone enjoy, the abstractions of Stockhausen's stark "Kreuzspiel" ("Cross-Play"), whose title refers to exchanges among oboe, clarinet, piano and percussion.
The preparation of high-quality pinhole-free perovskite layers for simplified planar architecture requires substantial effort.
Although switchable alkyl amine surfactants show promising results in laboratory tests for foam EOR, their application to field level still requires substantial effort.
Due to the incompatibility of the involved representations the transition from geometric modeling to mechanical simulation, as well as in the opposite direction, requires substantial effort.
However, the majority of these subsystems (1) are continuously foundational, i.e., ideally for each development period knowledge should be preserved, and (2) experience substantial changes, i.e., preserving knowledge requires substantial effort.
Assessment of historical environmental exposures often requires substantial effort, and the general methodology described here can be applied elsewhere.
The United States' multiple-payer health care system requires substantial effort and costs for administration, with billing and insurance-related (BIR) activities comprising a large but incompletely characterized proportion.
Measuring the developmental effects of proportionate universalism requires substantial effort in the form of establishing early and developmentally relevant baseline measures with ongoing capacity to monitor progress over time.
Etiologic diagnosis of CNS disease in cattle requires substantial effort; is costly; and usually presents a challenge because of the large number of pathogens or problems that can cause neurologic disease, including viruses, bacteria, parasites, prions, toxins, and metabolic disorders.
