Sentence examples for this required significant effort from inspiring English sources

This required significant effort and resources in order to successfully model the structure, which afforded the best Flack x parameter for these systems to date.

Unfortunately, Pfam lacks a sophisticated mechanism necessary for routinely matching published experimental data to database entries and relies on biocurators to annotate the entries; this requires significant effort and resources.

Extracting that information in order to allow searching has required significant effort.

Getting SLAM to work in a small embedded computer system required significant effort to refine and optimize the algorithms used.

Matching vehicles from the microwave sensor data and the ground-truth data manually collected required significant effort.

Manual methods used during anaesthesia, to decide and deliver the quantity of drug, required significant effort from the clinical standpoint not guaranteeing an optimal performance.

Afterward, he stumbled his way to the beach; haltingly, he mentioned that his therapist had (correctly) pointed out that he held much of his tension in his jaw; the resulting massage forced such relaxation that basic conversation required significant effort.

How many times have you had a customer problem that required significant effort to resolve, only to have the same problem happen again with another customer?

The Firebrand required significant effort by Blackburn to produce a useful aircraft and the first discussions on a redesign of the aircraft with a laminar-flow wing took place in September 1943.

However, these initial genotyping technologies were of relatively low throughput and required significant effort per data point.

In some sites creating a level living surface was relatively easy, whereas in others it required significant effort.