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All this repositioning has broken the concentration of a classmate behind me, who kicks my chair hard and menacingly whispers, "We all know you're farting, Meg.
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Drug repositioning has improved using this method as it is associated with a reduced failure rate especially if the drug has already been successful in gaining FDA approval [ 32].
The effectiveness of this method for in silico drug discovery and drug repositioning has been demonstrated already by its very first applications [36,37], and it highlights the potential of gene transcription profiling to serve as the common language to link chemistry, biology and the clinic, by inferring genome-wide similarities or differences [35].
The repositioning has reduced its client base by almost 70%, from about 30,000 accounts in 2007 to some 10,000 in 2014.
That repositioning has been ongoing.
Recently, the combination of metronomic chemotherapy and drug repositioning has been proposed as an attractive alternative for cancer patients living in developing countries.
Literature-based drug repositioning has been reviewed [ 20, 21].
Pain as a barrier to moving and repositioning has been noted by others [ 5, 27].
Therefore, drug repositioning has attracted enormous research interest from both academia and pharmaceutical companies.
However, little computational research on miRNA-based drug repositioning has been conducted.
Drug repositioning has become an increasingly important part of the drug development landscape, with many pharmaceutical and biotech companies now having repositioning programs (Arrowsmith and Harrison, 2012).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com