"My father's holding the twins, and we're all tight in this big crowd, waving, and Kennedy looks at us and points at this replication of what he had grown up with, and he had this big grin," he said.
This replication of the associations we observed in pregnant women in Boston supports a broader relationship between environmental phthalate exposure and measures of oxidative stress during pregnancy.
This replication of MP sequences is expected due to the PCR amplification processes involved in library assembly and is bioinformatically removed to prevent bias in library mapping.
The power for this replication of a GWAS finding [ 31] was about 42% in our study with 521 cases and 321 controls (using the reported OR = 0.83, minor allele frequency = 18% and one-sided P-value = 0.05).
The public sequence databases have recognized the need for controlling this replication of errors and provide validation software for checking the standard of one's annotation prior to submission [ 9, 10].
This replication of one UK PCD-based study in a second completely independent PCD, using the same methods and sampling the same population, has revealed a complex pattern of similarities and differences in both the makeup of the patient cohorts and in the findings from analysis.
