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This regimen is expected to result in continuous exposure to higher antibody titers.
However, for nerve agents that are more prone to reactivation than soman, this regimen is expected to show higher efficacy.
Thus, when different daily doses are required, the tool can visualize the variability in INR response that this regimen is expected to introduce.
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This high dose regimen is expected to result in sustained high drug levels in the liver [25], [26].
The marketed dosing regimen is expected to be 45 mg SC every 12 weeks.
The neutropenic response under the standard regimen is expected to be harsher than that with no G-CSF at all.
Using a perinatal exposure regimen is expected to mimic the "real life" exposure pattern of the Arctic human population.
The once-weekly regimen is expected to improve treatment compliance compared with other daily regimens such as once-daily liraglutide and twice-daily exenatide.
Under these premises, the LPV/r-containing ARV regimen is expected to be more beneficial in terms of genetic barrier to resistance and also a reduced propensity to lipoatrophy compared to the EFV-based regimen.
The BID dosing regimen is expected to achieve higher predose motesanib concentrations in the plasma than QD dosing owing to the higher total dose administered and more frequent dosing.
As such, the mean exposure of these regimens is expected to be in the 80% to 130% of the adult target when treated with darunavir/ritonavir 800/100 mg once daily (ARTEMIS study) for average AAG concentrations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com