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This regimen is consistent with data by Garonzik et al. [ 20], who, on the basis of pharmacokinetic analysis of CMS and colistin in critically ill patients, suggest that to obtain a colistin steady-state plasma concentration of 2.5 mg/L, a 70-kg patient with a creatinine clearance rate of 80 mL/minutes needs to receive a CMS loading dose of 10 MU, followed by a maintenance CMS daily dose of 10 MU.
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This dosing regimen is consistent with what is now regarded as standard treatment in NZ and many other countries.
The efficacy of our higher dose regimen is consistent with these data, whereas our lower dose regimen is among the least active of those described (Table 5).
Thus, our results showing better compliance with monthly regimen are consistent with recent ones on French prescription database [ 25].
Similarly, efficacy results for DI regimen were consistent with those reported in other studies, in which the response rate was 26% and 45.7%, respectively (Jatoi et al, 2002; Park et al, 2006).
This strategy (adding an agent rather than changing regimens) is consistent with observations in patients with HER2-positive metastatic breast cancer that continuation of trastuzumab beyond progression can be beneficial [ 46] as well as our observations on resistance and retreatment [ 47].
Overall, the pattern of QL differences between the two regimens was consistent.
Multiple trials testing different types of exercise regimens are consistent in showing that exercise alleviates pain from knee OA.
GI disorders, which occurred primarily with the activated charcoal-containing regimens, were consistent with the known tolerability profile of activated charcoal [ 34]; seven of the eight emeses occurred within 2 h following administration of activated charcoal.
This regimen is safe and well tolerated.
This regimen is active in a variety of malignancies.
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