Along this vein, several previous studies implicated the random mode of cell migration in tumor progression.
In CSMA/E2CA, a station that suffers two consecutive unsuccessful transmission attempts switches to the random mode of operation.
Then, a single collision (or channel error) is not enough to move a station from the deterministic mode of operation to the random mode of operation.
"But when we put them up against a very sophisticated competitor … the animals switched to the random mode".
Conceivably, by regulating microtubule dynamics, NAV3 inhibits the random mode of cell migration and restrains dissemination of tumor cells.
This study identifies NAV3 as a suppressor of breast cancer progression and proposes that the ability to stabilize microtubules and inhibit the random mode of migration restrain metastasis.
However, the random mode was less than half as efficient as aDBS, implying that intermittent stimulation has to be triggered by beta bursts to have its optimal effect.
In other words, the quantitative modeling we performed implied that loss of NAV3 would bias the random mode of cell migration.
Then OptiCells containing subconfluent monolayers were fixed onto the RPM, as close as possible to the center of the platform, which was rotated at a speed of 60°/s using the random mode of the machine.
