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More important topics had more test questions, and confusing questions were clarified or eliminated over the years of teaching this class.

"That is being worked on under high pressure, and once these legal questions are clarified, then the operations can be ordered".

As a result of pilot testing, the wording of some questions was clarified.

To define the research context, objectives and research questions were clarified using the population, intervention, comparison, and outcomes (PICO) tool.

In Round 3, 'core' questions to be used in international comparisons were identified, questions were clarified or eliminated, and feedback on administration of the questionnaire was given.

Thereafter some minor adjustments were made in the layout of the questionnaire and some study specific questions were clarified to reduce the risk of misinterpretation.

S100 proteins can be externalized by an alternative pathway different from the standard secretory pathway, but this question is not definitely clarified.

If HDL endocytosis and resecretion also contribute to macrophage cholesterol homeostasis, remains to be clarified (this question is also addressed by a review article by Cavelier and colleagues [84]).

This question was eventually clarified when it was shown that the fungus interferes with ROS accumulation by releasing oxalic acid, a calcium chelator, at the infection site [ 5].

We feel this question is of fundamental importance in clarifying whether this phenomenon is a common property of synaptic information encoding shared by different species or is a unique rat-specific phenomenon (Kemp and Manahan-Vaughan 2007).

This question is particularly relevant in order to clarify the biological basis of psychiatric diseases, such as OCD, in which a dysfunction in error processing (obsession) leads to the maintenance of inappropriate behavior (compulsion) [40].

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