Sentence examples for this protein targeted from inspiring English sources

Our study unravels the identity of this protein targeted by PNP autoantibodies as the protease inhibitor A2ML1.

This protein targets NRF2 for Cullin3/Rbx-mediated ubiquitination and subsequent proteasomal degradation.

In addition, WoLF PSORT software analysis predicted that the most probable localization of pmCiC would indeed be the plasma membrane (with a probability of 75%), with a 0% probability of this protein targeting mitochondria.

To date, there is an urgent need for further development of the design and synthesis of APE1/Ref-1 inhibitors due to high importance of this protein target.

Molecular docking studies using this protein target have also not yet been reported.

The two groups disagreed about whether the modifications were reversible and which cysteines were required for the modification, and neither group considered the potential role of this protein target in chemoprevention.

Third, patients in the trial received a low protein delivery (median of 0.8 g/kg/day protein (after day 3)) for the study period in the early PN group; this protein target is below what is recommended by most guidelines for critically ill patients (the typical recommendation is 1.3 to 1.5 g/kg/day (ESPEN guidelines)).

This, along with the protein targets identified herein, is suggestive that the pyrazolone binding site differs from the substrate binding site occupied by MG132.

A knowledge of the proteins targeted by this modification is thus of utmost importance in deciphering its impact on the biology of the organism.

As well, the effect of subcellular targeting on protein activity has been observed with human gastric lipase produced in tobacco; however, in this case, the vacuolar-targeted enzyme exhibited two-fold lower specific activity compared with the same protein targeted to the apoplast or ER, probably due to proteolytic-induced instability of this specific protein when targeted to the vacuole [ 35].

How membrane proteins are able to adapt specifically to their surrounding heterogeneous matrix, and whether this environment affects protein targeting and function, is therefore a matter of particular interest.