Chaney and Morris first proposed mRNA secondary structure as the primary cause of non-uniform translation [ 129].
The other view proposes mRNA decay occurs in concert with protein synthesis.
To sum up, this study proposes DDC mRNA expression as a useful biomarker for better classification of the laryngeal and tongue tumors.
This model proposes that mRNA expression of cyclin D1 is negatively regulated by p65 through the interference of β-catenin binding on the TBE0 site.
Furthermore, Duan and colleagues [7] proposed that mRNA stability imposes strong selective pressure on synonymous codon usage and it is likely that this is also true for codon-pair context.
Several hypotheses have been proposed regarding mRNA transport, such as transport on microtubules, or on microfilaments, or via diffusion throughout the cytoplasm, controlled by the size of the mRNA and not by its sequence [35], [36], [37], [38], [39], [40], [41].
Two mechanisms for the regulation of target genes by miRNAs have been proposed: target mRNA cleavage and translational repression.
Multiple data-driven models have been proposed for mRNA translation, where one is usually satisfied as long as the model matches the available experimental data (and possibly makes a few additional predictions successfully).
However, the proposed plu1752 mRNA 5'UTR secondary structure closely resembles that of the P. luminescens ompF 5' UTR and the 28 base insertion between positions 92 93 of the ompF 5' UTR does not appear to perturb the large stem loop, the primary ompF 5' UTR structural motif.
Briefly, the best characterized function of poly(A -tail-bound PA -tail-boundcing trA -tail-boundtiation by interacting with translation initiation factors bound at the 5′-end of the mRNA: this is PABP1sed to stabisizenhancingntranslationinitiationthereby enhancinteractingruitment of ribosomal subunits.
