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Yet all of this promising activity is precarious, powered only by optimism and determination.
Based on this promising activity, currently, a phase 3 study is running in liposarcoma and leiomyosarcoma (NCT01327885).
This promising activity was demonstrated together with a more favorable toxicity profile than that of commonly used platinum two-drug combination regimens.
Based on this promising activity a phase 3 study was designed by EORTC STBSG, in which pazopanib was compared with placebo in a 2 1 fashion in patients with progressive non-adipocytic STS, who had had anthracyclines and standard treatment for STS in their country.
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Collectively, this work demonstrated the promising activity of the newly designed compounds as leads for further development into antiproliferative agents.
Several compounds from this library revealed promising activity during a cytotoxicity screen.
Initial biological studies indicated that this compound showed promising activity against HCV replication.
This combination shows promising activity in the treatment of solid tumors.
This regimen showed promising activity with moderate toxicities in advanced gastric cancer.
Although CD52 expression on malignant T cells varies considerably [ 18], this antibody showed promising activity in trials of various T cell lymphomas [ 19– 22].
This study shows that the RP2D of docetaxel is 30 mg/m in phase I, and this triplet therapy has promising activity with an RR of 62% and a median OS of 11.1 months in phase II.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com