Sentence examples similar to this progression is problematic from inspiring English sources

This dichotomous role of TGFβ signaling with respect to tumor progression is problematic for strategies to target aberrant TGFβ signaling in cancer.

Weight loss is the most frequently used clinical biomarker in disease studies, but reliance on changes in body weight as a single indicator of disease progression is problematic (Franco et al, 2012) particularly in cancer research due to the weight of the tumours.

Thus, frequent recurrence after TUR and subsequent cancer progression are problematic for patients and urologists alike.

Methods for scoring disease progression are problematic [ 31].

This disconnect is problematic.

This construct is problematic.

But this analogy is problematic.

"This guy is problematic for me.

This strategy is problematic, however.

But this move is problematic.

This term is problematic in various ways.