Convention dictates that sunitinib is continued until evidence of disease progression, assuming tolerability, although there is no evidence that this approach is superior to intermittent periods of treatment.
A simple progression assuming 30% quarterly growth and a starting estimate for fiscal first quarter Lync revenue of $150 million tracks out to $195 million in the second quarter, $253 million in the third, and $329 million in the fourth.
Estimating MI does not require sampling the random processes in any specific time progression (assuming d≥L) and it is, therefore advantageous to arrange the analysis to use the most mutually dependent samples.
The former group, although apparently not frequently methylated in primary tumours, might be considered as candidate genes implicated in progression (assuming that acquisition of methylation in cell culture might have a growth advantage).
Furthermore, based on the results obtained from clinical samples, we examined the mechanism by which GPNMB contributes to tumor progression, assuming that a cross talk between GPNMB and HER2 exists through shared signaling pathways.
To reflect disease progression, we assumed that all HIV-infected people progress from primary/acute HIV infection, to chronic/asymptomatic infection, to a treatment-eligible stage, and then may receive treatment (Fig. 1).
Incidence of proliferative diabetic retinopathy is derived from data on the progression to retinopathy by duration of diabetes (male and female progression is assumed to be the same; insufficient data were available to separate by sex).
This instrument assumes that respondents follow normal progression through school (i.e., they do not repeat or skip grades)11.
For the environmental context dimension, the same pattern of progression is assumed.
Another limiting factor is CVD progression generally assumed as irreversible and one-directional [ 9].
