The senescence program is activated by a variety of signals, including progressive loss of telomeric sequences during repeated rounds of DNA replication, other forms of DNA damage, and the oxidative and nutritional deficiencies present under tissue culture conditions.
Our observations indicate that the cellular senescence program is activated by both Aplidin analogs PM01215 and PM02781.
During the second stage, as ECG files are received successfully, the ECG decoding program is activated by the previous Web Role-ECG receiver through the notice of the queue, which is also a special data format in the Azure.
Genomic studies at transcriptional and proteomic level are revealing that the dissection of signalling pathways has not completely defined all the required elements necessary to maintain muscle mass neither identified whether a common "atrophy program" is activated by the various perturbations that produce the atrophic response.
In the neonatal mouse lung, the senescence program was activated by hyperoxia via decreased histone deacetylase activity and upregulation of p21, contributing to impaired alveolarization [34].
In response to extracellular signals, appropriate gene expression programs are activated by combinatorial interactions among transcription factors (TFs).
During inflammation, gene programs are activated by orchestrated changes in transcription and are determined by transcription factors (TFs) binding to accessible DNA regulatory elements found in promoters and enhancers.
Columbia has a year-long celebration of its bicentennial with the theme "Man's Right to Knowledge and the Free Use Thereof". A major campus building program is activated and, by the end of the following decade, five of the University's schools are housed in new buildings.
Our data suggest that in sensitive fruit a cold response program is activated and regulated by auxin distribution and ethylene and these hormones have a role in sensitivity to CI even before fruit are cold stored.
Our findings indicate that by direct inhibition of this signaling molecule, the OPC differentiation program is activated resulting in morphological and functional cell maturation, myelin formation, and regeneration.
To address whether this gene program was activated in LCR hearts we analyzed other markers of the fetal gene program (e.g. transcript levels of β-MHC, BNP, and α-skeletal actin analyzed by qRT-PCR).
