The intravitreal injection of IL-1 β accelerates the apoptosis of retinal capillary cells via the activation of NF- κB, and this process is exacerbated under high-glucose conditions [ 32].
This process is exacerbated by defective cytoplasm-to-ER transport of calcium owing to lipid-mediated sarco endo)plasmic reticulum Ca+2 - ATPase (SERCA) inactivation (Fu et al. Nature, 2011, 473:528–31; Park et al. Proc. Natl. Acad. Sci. U.S.A., 2010, 107:10720-5).
The lack of clear guidance in the environmental review process was exacerbated by high turnover among scientists at the agency, many of whom said in interviews that they left for other jobs because they had been pressured to rewrite their work or had it rewritten for them and that they were perceived as obstacles in the way of drilling.
Meanwhile, as Vulture reported, the messy post-production process was exacerbated further by the fact that Pitt and director Marc Forster ("Quantum of Solace") weren't on speaking terms.
Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated.
Problems in due process are exacerbated by the widespread use of wiretaps by law enforcement officials.
It is estimated that the fatigue crack initiation process is exacerbated by heavy overlaps and excessive rigidity created at the joint node by the current design, which is often based more on practical experience in field than following any design standards rigorously.
This process is usually exacerbated by construction of roads, causing erosion and allowing previously inaccessible areas to become colonized by people (Kalliola and Flores Paitán 1998).
This process is further exacerbated at weaning when acute inflammation may occur as a result of a complex cascade of events which often ends in microflora imbalances in favors of harmful species.
