After 2 weeks of therapy, the number of selected sites increased in all three groups, but the character of the pressure operating globally in HVR1 remained unchanged.
Because selection pressure operates at the level of function, which is encoded in distinct domains, it is reasonable to study the relationship between diversification in distinct domains.
We hypothesized that mutation patterns in CD8+ epitopes may provide important clues to what kind of immune selection pressure operates on CHIKV.
The extent to which function-selective pressure operates upon genome evolution remains an open question.
Therefore, it appears to be unlikely that the evolutionary pressure operates directly on the 'domain quantity' but acts in the 'architectural context' of the functions instead.
Evolutionary operators function at the level of the binary string (the genome), while the selective pressure operates at the level of the accuracy of the NN (the phenotype).
The existence of this selection pressure operating independently of DNA methylation induced mutation is supported by our finding of mutational biases against CpG dinucleotides among RNA viruses in which conventional deamination and mutation as a consequence of methylation cannot occur.
This is easily accounted for by the enormous selection pressure operating on the translation machinery (made of proteins interacting with each other and with highly conserved RNAs), which cannot easily accommodate mutations resulting in alteration of the corresponding proteins.
This article describes the physical conversion of a standard positive pressure operating theatre into a negative pressure environment, problems encountered, airflow design, and evaluation of performance.
This chromosomal instability, affecting large chromosomal regions, is the substrate of a strong selective pressure operating on a reduced number of cellular functions leading to cancer [ 37].
