The direction of the change (the observed shifts toward the c1 position) implicates a decrease in density of the FeS cluster at the Qo site which, as judged from the differences in the extents of the effects, appears to be more pronounced in the case of antimycin than in the case of myxothiazol.
Comparing sequence differences between LG/J and SM/J alleles, we noted that Xrcc2 contains a nonsynonymous change in exon 2 Gly:26 Ala at a highly conserved position, implicating this particular SNP as a functional variant relevant to healing in the LGXSM intercross.
Among the divergent sites, at a position implicated in the charge clamp necessary for coactivator contact, amphiER contains an aspartate (D677) instead of a glutamate in humanERα (E542).
Two isolated antibodies from vaccine recipients, CH58 and CH59, bind to lysine 169 in gp120 V2 (Liao et al., 2013), a position implicated by sieve analysis in blocking sequence-matched HIV-1 strains.
Whereas abundant putative Ser/Thr phosphorylation sites are found in the C terminus of all V2R orthologs the putative PKA phosphorylation site within ICL3 at Ser255 [41] is substituted by Asn, Gly and Asp in many V2R orthologs implicating that this position is, if at all, a substrate for PKA in only a few species.
Collectively, these findings suggest that a Glu-to-Lys mutation at position 627 of the PB2 protein allows avian viruses to efficiently grow in humans and implicates Lys at this position as an important host range determinant.
(A tendency of the counting methods to produce more conservative results than the random-effects method has been reported previously [27].) Three of the 14 positions implicated by the latter method as being positively selected (134, 145, and 152) are in the highly variable 3' portion of exon 5 (Figures 3 and 5).
We binned these putative IES positions as one of three window (win) designations: (1) IES positions implicated by converging L and R alignments with terminal MAC-matching positions separated by no more than 9 bp (win1 category, 404 sites), (2) IES positions implicated by L alignment(s) only (win2 category, 1378 sites), or (3) R alignment(s) only (win3 category, 1469 sites).
In bold we highlight those co-evolving amino acid positions reported to be involved in dimmer formation of hAng, in Italic we remark positions implicated in the interaction with angiogenin-inhibitor in Human.
