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When functioning in the direction of acetate synthesis, this pathway serves three functions: 1) to incorporate Pi, 2) to recycle coenzyme A (HS-CoA) and 3) to produce ATP.
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Thus the cause of the lower Hcy levels in Nox4-/ mice is not due to increased flux through the folate-dependent remethylation pathway since inhibition of this pathway served only to increase the difference in plasma Hcy levels between Wt and Nox4-/ mice.
This signaling pathway serves to communicate mitochondrial dysfunction to the nucleus to induce an appropriate transcriptional response.
Frequently, an end-product of a metabolic pathway serves as an allosteric inhibitor on an earlier enzyme of the pathway.
The PD-1 pathway serves as a critical regulator of T-cell exhaustion state (Freeman et al., 2000).
The Rho/Rho kinase (ROCK) pathway serves as molecular switches in many biological processes including the immune response.
Recent study showed that the ATM-BID pathway serves as a critical checkpoint in the homeostasis and DNA-damage-induced cell death of HSCs (Maryanovich et al., 2012).
The carotenoid biosynthetic pathway serves manifold roles in plants related to photosynthesis, photoprotection, development, stress hormones, and various volatiles and signaling apocarotenoids.
Evidence is emerging that HIF-1α, a central downstream element of STAT3 pathway, serves a pivotal role in the complex signaling network with subsequent diverse cellular events.
Then the tension became, which pathway serves which students?..
The miRNA pathway serves as an important post-transcriptional regulation mechanism [1].
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