The interactions observed for genes involved in tryptophan, cysteine and serine biosynthesis suggest commonality in stress-induced regulation of these pathways encompassing a community of gene loci acting together as a subnetwork.
However, no specific pathway encompassing all of the commonly differentially expressed genes could be discerned.
Its presence in livers of young children with end stage hepatic disease, characterized by SA- βgal activity accompanied by changes in the classical senescence pathway encompassing activation of p53, p21cip1 and p16INK4a, as found in the present study, support the concept that the loss of replicative capacity of the hepatocytes is related to liver damage.
The breast cancer estrogen signaling pathway encompassed a set of genes that were dysregulated in estrogen receptor dependent breast cancers.
Finally, mutant mice that reproduce AV block and congenital heart defects were vital in elucidating a molecular pathway, encompassing Nkx2.5, Tbx5 and Id2, that is essential for development of the cardiac conduction system and is compromised in Holt-Oram syndrome [ 19- 21].
It is noted that these pathways encompass a number of different biological processes, including amino acid biosyntheses, respiration, the TCA cycle, glycolysis, fatty acid biosynthesis, and other metabolism pathways.
Pathways encompasses questions on how CTP influences intermediate outcomes, outcomes, and impact, as well as routes to effectiveness.
Interestingly as anticipated the terpenoid and diterpenoid biosynthesis pathways encompasses the largest number of transcripts related to secondary metabolites, which may relate with the capacity of E. fischeriana root to produce prostratin and related diterpenoid compounds.
This approach may be used in future to dissect diverse and overlapping biochemical pathways encompassed by the identified transcripts at individual level.
