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This pathway contained several hallmarks of PD.
This pathway contained 27 genes with a highly significant score of 51.
This pathway contained five pectinesterase proteins, a polygalacturonase, and a UDP-glucose 6-dehydrogenase that overlap with the Starch and sucrose metabolism pathways.
The complete model indicated that this pathway contained an up-regulated enzyme, trans-pentaprenyl transferase (EC:2.5.1.33), which was not significantly up- or down-regulated in either the Northern or Southern genotypes analyzed separately.
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So what must this pathway contain?
Our data show that this pathway contains some elements that may belong to the canonical Wnt-pathway.
As found by others using the same dataset with the conventional ORA method [43], "Cholera – Infection" is related to tumorgenesis since this pathway contains genes such as adenylate cyclase signaling and phospholipase C that are changed in tumor cells.
After a detailed analysis of the predicted pathway annotations of signalogs, we found that in each of the three species the EGF/MAPK pathway contains the largest portion of signalogs (25% of the signalogs in the in worm, 42.5% in the fly and 28.6% in humans), which is consistent with the fact that this pathway contains the highest number of signaling components [22] (see also Fig. 2).
This pathway contains five species with each species coded in a particular color.
The part of this pathway containing selected genes is visualized in Figure 7a.
This pathway contains 56 significant differentially expressed genes from our gene list.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com