This pathway consists of two transmembrane segments plus an extracellular linker.
The highly conserved general architecture of this pathway consists of two modules which mediate signal transduction and adaptation.
This pathway consists of three enzymes: l-arabinose isomerase (which converts l-arabinose to l-ribulose), d-psicose 3-epimerase (which converts l-ribulose to l-xylulose), and l-xylulose reductase (which converts l-xylulose to xylitol).
This pathway consists of five reaction steps that connect d-xylose to the TCA cycle intermediate α-ketoglutarate.
There was differential regulation of genes in the tyrosine degradation pathway; this pathway consists of a cluster of six genes, four of which (AFUA2g04200 (hppD), AFUA_2g4210, AFUA_2g04220 (hmgA), AFUA_2g04230 (fahA)) were up-regulated during the interaction between A. fumigatus and iDC.
This pathway consists of several steps and is sometimes called the 'carnitine shuttle' (Fig. 3).
Key elements of this pathway consist of hypotheses specified by developers of therapeutics, a competitive research process, randomized studies in clinically relevant animal models and critical appraisal, possibly including meta-analysis of animal data.
This pathway consisted of the mTORC1 complex (mTOR, GBL, Raptor), the mTORC2 complex (mTOR, GBL, AVO3), the immediate downstream targets of mTOR – RPS6KB1 and RPS6KB2, and the upstream effectors of mTOR – AKT1, AKT2, TSC1, TSC2.
We believe that the common disruption of this pathway is a novel discovery, as this pathway, consisting of 17 genes, has not been reported as an indicator of LUAD in any of the studies we acquired datasets from (GSE10082, GSE7670, GSE10072), nor in a literature search with key words.
Notably, this pathway consisted primarily of genes from the top network involving candidates that were downregulated in shGR-19 relative to EV-50, including Nr3c1 itself, suggesting that these biological signaling pathways predominantly involve factors that are positively regulated by unliganded GR.
The core of the pathway consists of proteases of the caspase family.
