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This pathway comprises, amongst others, three reverse steps of β-oxidation, catalyzed by three separate enzymes: β-ketothiolase, 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase reactions.
15 This pathway comprises a physically and functionally distinct sub-compartment of the brain circulation.
In essence, this pathway comprises the enzymes under study: GFAE, ADH3 and SFGTH.
This pathway comprises cellobiose phosphorylase (CBP), which cleaves intracellular cellobiose into glucose and glucose-1-phosphate (G1P) [ 12].
This pathway comprises genes responsible for signaling events downstream of the CD28 superfamily of receptors that are required for the activation of T lymphocytes (in conjunction with the T cell receptor complex).
This pathway comprises part of Arginine and Proline metabolism [ 34] with all the reactions between AcCoA and Ac catalyzed by highly-expressed enzymes i.e. all reactions included in H.
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The activation of this pathway, comprised by Ras, Raf, MEK1/2 and extracellular signal-regulated kinase (ERK 1/2, leads to tumour development and progression through the activation of transcription factors that stimulate cell proliferation and metastasis (Dhillon et al, 2007; Katz et al, 2007).
However, the pathway comprises a multitude of signaling molecules and displays complex interactions.
This metabolic pathway comprises the four transmembrane enzyme complexes (CI IV) of the mitochondrial respiratory chain and Complex V, the FoF1-ATP synthase.
This signaling pathway comprises numerous extracellular ligands (such as activin A, myostatin, nodal), transmembrane receptors [such as activin receptor type IIB (ActRIIB), TGFβ receptor type II] and intracellular signal transducers (SMAD proteins) (Schmierer and Hill, 2007).
Finally, the pathway comprised 30 nodes and 38 edges (Fig. 1).
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