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Phylogenetic analysis of 8 GBM patients revealed that the SVZ contains early clones in 4 out of 8 cases suggesting that this niche represents the "area of origin" of the tumor and also pointing to the neural stem/progenitor cells as the best candidate of malignant transformation.
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A synthetic material that closely mimics the composition and structure of the human osteogenic niche represents great potential to successfully address this high demand.
In the case of bioenergy crops, the climate niche represents both the region (possibly) suitable for agronomic production, as well as the regions (possibly) suitable for establishment outside of cultivation [18].
All together these results indicate that the osteoblastic niche represents a dynamic space where hMSCs differentiated into hOSTs physically interact with HSCs and provide a quiescent environment, while surrounding undifferentiated hMSCs might support HSC differentiation towards the megakaryocytic lineage.
Here we propose that the prevalence of infectious pathogens in a given niche represents an additional environmental factor that, via innate immune pathways, actively shifts this balance in favor of somatic maintenance at the expense of reproduction and growth.
The ability of a stem cell to seed in its niche represents one of the most important features of the niche itself, and the proper binding between stem cells and their niche is essential to maintain the stem cell pool for long-term self-renewal.
Within biodiversity studies, in which the concern is typically with the conservation of the extant habitat of a species, this fundamental niche (representing a potential distribution) is typically restricted to a realized geographical niche by using additional information such as confirmed occurrence records for a species within each accepted contiguous piece of modelled suitable habitat [10].
Mr. Tanner has carved out a niche representing professional basketball players.
Mr. Glazer has developed a niche representing real estate developers proposing controversial projects.
But Williams & Connolly has also carved out a niche representing talent across the entertainment industry.
The company had devoted American customers, but its niche represented less than one per cent of the yogurt market.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com