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This motif features a universally conserved glycine residue 15 amino acids upstream of a 3 residue hydrophobic cluster [ 23].

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Prediction model: within each interval i, the model integrates a set F of up to three features (always including the motif feature, f = 1) by a weighted sum of thresholded feature values.

The novel moves from seasonal warmth to seasonal warmth, from October , 1990 to August , 1991 but for much of the time Prague's weather seems in a state of wintry arrest: a comic motif features the daily existential struggle, for a man blessed by easy American sunlight, with the gray baffle of the city's skies.

The building's facade looks as if it was imported from a ghost town in Oregon, and the interior, also decorated in a western motif, features Frederic Remington etchings and equipment that would be more at home on the range and the ranch than at a New England watering hole.

Protein motif features were predicted by the Simple Modular Architecture Research Tool (http://smart.emblheidelberg.de/) (Schultz et al. 1998).

Motif features differ from k-mers since they are approximate sequence matches instead of an exact match.

Table 1 Average performance of models trained to classify into Hominidae or one of the listed clades The table shows a comparison between IT and k-mers + sequence motif features.

A feature vector d = (d1, d2,.., dqd)T is defined for each protein, where qd is the total number of protein motif features (qd = 992 in our case).

These motif features are also used as predictors in our model.

To improve classification accuracy, a wrapper-based feature selection method [ 66] was further applied to choose informative motif features.

For each feature (740 TF or motif features), the values are sorted across all genes and then set to the average of distributions.

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