Sentence examples for this modification implicates from inspiring English sources

This modification implicates the MLL1-associated MOF histone acetyltransferase as the dominant activity maintaining transcription of MLL1 target genes.

Hence, variations among cell types in this type of modification implicates mechanisms different than those involved in focal peak dynamics.

Ubiquitination is not the only covalent modification implicated in proteolysis and neurodegeneration.

An additional post-translational modification implicated in neurodegeneration is phosphorylation, which can vary between soluble and aggregated states.

SUMO (Small Ubiquitin-like MOdifier) conjugation is a post-translational modification implicated in a variety of cellular functions including transcriptional regulation, nuclear location and signal transduction.

Interestingly, another modification implicated in epigenetic memory, methylation of lysine 4 on histone H3 (H3K4 methylation), is noticeably depleted during Z2/Z3 reprogramming.

An Arf/Arl/Sar co-conserved tryptophan within the C-terminal end of the GTPase domain Trp172-Arf11 in Fig. S2C of Additional File 1) is located structurally near the N-terminal myristate moiety [ 22]--a posttranslational modification implicated in membrane association and a feature required for the biological function of Arf GTPases.

Like wt DRIL1, all the SUMO mutants were able to bypass both spontaneous and activated RAS-induced senescence (data not shown), reaveling that this modification is not implicated in this process.

Considering the high abundance of mA in a large number of mRNAs, it is not surprising that this modification has been implicated in a wide range of cellular processes, and is likely to play an essential role in development and tissue differentiation by modulating cell fate and survival, stress responses, meiosis, the circadian clock, as wells as cellular immunity [ 47,49,52,54 56].

3a Global studies to identify proteins that undergo disulfide bond formation implicate this modification in the regulation of, among others, redox homeostasis, chaperone activity, metabolism, transcriptional regulation, and protein translation.

Genetic evidence in yeast has implicated this modification in an error-free pathway of damage avoidance that likely involves template switching, but the mechanistic aspects of the reaction are unexplored (Hoege et al. 2002; Zhang and Lawrence 2005).