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H3K4 trimethylation is a marker of transcriptional active chromatin, and this modification contributes to gene activation [64].
Whether this modification contributes to the stability of cytosolic proteins such as THB1 is not known.
Our data show that this modification contributes to the stability of Pex5p, whereas all other examples aim to enhance the degradation of the substrates.
Phosphorylation at Ser20 enhances p53 tetramerization, nuclear accumulation, stability and transcriptional activity, and therefore it is likely that this modification contributes to the stability and increased levels of nuclear p53 seen in response to PERP expression.
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Further, this NEMO modification contributes to TRAF6-mediated activation of NFκB.
This data implies that protein O-GlcNAc modification contributes to the oxidative stress tolerance that is prominent in insulin pathway mutants.
It remains possible that this modification also contributes to transcriptional quelling, supported by the observation that, in budding yeast, H3K36me2 is sufficient to suppress cryptic initiation and elicit Rpd3s mediated effects [162,163].
In wind energy resource assessment, tower-induced flow modification contributes a non-negligible amount of uncertainty to the wind resource assessment.
Moreover, epigenetic deregulation, especially histone modification, contributes to the deregulation of HOX genes in cancer.
Promoter methylation, along with histone modification, contributes to MT1G inactivation in thyroid tumorigenesis.
Furthermore, we showed that histone modification contributes to leptin's gene regulation in HCC.
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