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Here, we explore the possibility of extending the loops between repeats to enable further diversification, and we investigate how this modification affects stability and folding cooperativity.
PATs are interesting targets for drug design since they modify oncoproteins, and this modification affects their activity.
Given that Ey(2a) has additional amino-acids immediately upstream from its paired domain, it is possible that this modification affects its binding ability and/or specificity.
The presence of this modification affects membrane fluidity and influences antimicrobial peptide resistance.
This type of modification has been shown to alter cannabinoid receptor binding, but it has not been demonstrated whether this modification affects the interactions of these compounds with Cav3.2.
X-linked protein-coding genes are underrepresented among genes differentially expressed in our contrasts (Table 1), consistent with the hypothesis that such epigenetic modification of the X chromosome would be concentrated in heterochromatic regions and that this modification affects gene expression genome-wide in trans.
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The weakening of a typhoon means that surface wind weakened, leading to the vertical turbulent mixing in the oceanic mixed layer being modified, and this modification affecting the cooling of the sea surface.
Note that this modification affected the following gap analysis in that compartment specific gaps were not considered for gap filling; e.g., a reaction present in mitochondria but missing in cytosol would not result in a gap in the decompartmentalised network.
Wnt proteins contain a lipid adduct that is required for activity ([1]; reviewed in [27], [28]) but precisely how this lipid modification affects the intercellular transport of Wnt proteins is unclear.
Interestingly, the p Ka of carbofluorescein is 7.4, a full unit higher than that of fluorescein, demonstrating that this structural modification affects chemical as well as spectral properties.
This epigenetic modification affects tumor suppressor genes involved in regulation pathways, cell cycle control, cell adhesion and extracellular matrix degradation, in a sequential and cumulative way.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com